Usbio/C7905-85抗CpG DNA，小鼠，生物基因组学与贸易/200nmol/C7905-85
商品编号：
C7905-85
品牌：
USbiological
市场价：
¥13300.00
美元价：
5652.50
产品分类：
克隆基因
公司分类：
Cloned_Genes
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
BacterialDNAisknowntoinduceacuteinflammatoryresponses.BacterialDNAactsasapathogen-associatedmolecularpatternbyvirtueofa20-foldgreaterfrequencyofunmethylatedCGdinucleotidesfoundinmicrobialDNAversusvertebrateDNA.Cellularactivationbydeoxy-cytidylate-phosphate-deoxy-guanylate(CpG)-DNAoccursviatheToll/IL-1Rsignalpathway.TLR9appearstobeamajorcomponentoftheCpG-DNAreceptor,actingbydirectbindingtoCpG-DNA.Thesyntheticoligodeoxynucleotides(ODN)containtheproperCpG-DNAmotifmimicingtheimmunostimulatoryeffectsofbacterialDNA.ThehumanoptimalCpGmotifGTCGTTdiffersfromtheoptimalmouseCpGmotifGACGTT.NonCpG-DNAhasbeenshowntocompetewithCpG-DNAininvitrostimulationexperiments.||Source:|ThismouseCpGisa20-merODNhasthefollowingsequence:5'-tccatgacgttcctgatgct-3'.Regularlettersrepresentphosphorothioratelinkage.||Applications:|SuitableforuseforBIOLOGicalassaysinvitrotoactivatemurinecells.Otherapplicationsnottested.||RecommendedDilutions:|InvitroStimulation:0.01-10uM|Optimaldilutionstobedeterminedbytheresearcher.||StorageandStABIlity:|Lyophilizedpowdermaybestoredat-20°C.Stablefor12monthsat-20°C.ReconstitutewithdH2O.Aliquottoavoidrepeatedfreezingandthawing.Storeat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.
品牌介绍
usbio的生化试剂，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。
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