Astroviruses are non-enveloped, positive-sense single stranded RNA viruses that belong to the Astroviridae family. Originally identified in stools from infected children, astroviruses have since been found to infect numerous mammalian and avian species, and have been classified into two genera Mamastrovirus (MAstV) and Avastrovirus (AAstV) respectively (Bosch, A). Human astroviruses (HAstV), of the genera Mamastrovirus, predominantly infect young children below the age of 5 years, and cause mild symptoms of diarrhea, vomiting and fever. HAstV infection can also cause gastro-intestinal illness in the elderly and in immunocompromised adults, which may be more severe and of longer duration (Vu, DL. 2016). Initial immunological studies identified eight distinct serotypes of HAstV that cause diarrhea in children, with serotype 1 being the most prevalent. These serotypes are referred to as classic HAstV’s. Phylogenetic studies have identified two novel groups of astroviruses that also infect children. These novel HAstV’s were first identified in Melbourne Australia (HAstV-MLB) and in Virginia, Nigeria, Pakistan and Nepal (HAstV-VA/HMO). Currently, very little is known about the epidemiology or pathogenesis of novel HAstV’s but studies suggest that novel HAstV’s may cause clinical complications, affecting the central nervous system, in immunocompromised patients (Vu, DL. 2017).||Applications: |Suitable for use in ELISA. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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