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Usbio/143742 Cathepsin D BioAssay™ ELISA Kit, Mouse/143742/96Tests
Usbio/143742 Cathepsin D BioAssay™ ELISA Kit, Mouse/143742/96Tests
商品编号：
143742
品牌：
USbiological
市场价：
¥14980.00
美元价：
6366.50
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Sandwich ELISA quantitative detection kit for Mouse Cathepsin D in cell culture supernates, serum and plasma (heparin, EDTA).
Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of the peptidase C1 family, having a specificity similar to but narrower than that of pepsin A. It is mapped to 11p15.5. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in a pre- and prosegment, respectively. Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease and it has been considered as a breast cancer tumor marker.
Assay Range
156pg/ml-10,000pg/ml
Sensitivity
< 10 pg/ml
Crossreactivity
There is no detectable cross-reactivity with other relevant proteins.
Uniprot ID
P18242
Entrez Gene ID
13033
Kit Components
96-well plate pre-coated with anti-Cathepsin D, MouseLyophilized recombinant Cathepsin D, Mouse standard, 10ng/tube, 2EaUSB Cat Not Kit Component143696t Avidin-Biotin-Peroxidase Complex (ABC), 130ul (1:100 dilution)143697t Sample diluent buffer, 30ml143698 t Antibody diluent buffer, 12ml143699 t ABC diluent buffer, 12ml143700 t TMB color developing agent, 10ml143701 t TMB stop solution, 10ml
Storage and Handling
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
References
1. Faust PL, Kornfeld S, Chirgwin JM (Sep 1985). "Cloning and sequence analysis of cDNA for human cathepsin D". Proc Natl Acad Sci U S A 82 (15): 4910–4. |2. Wolf M, Clark-Lewis I, Buri C, Langen H, Lis M, Mazzucchelli L (April 2003). "Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer". Am. J. Pathol. 162 (4): 1183–90.|品牌介绍
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