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Usbio/491876 Rabbit Anti-SLC19A1 (Folate Transporter 1, Solute Carrier Family 19 (Folate Transporter), Member 1)/491876/100ul
Transportoffolatecompoundsintomammaliancellscanoccurviareceptor-mediatedorcarrier-mediatedmechanisms.Afunctionalcoordinationbetweenthese2mechanismshasbeenproposedtobethemethodoffolateuptakeincertaincelltypes.Methotrexate(MTX)isanantifolatechemotherapeuticagentthatisactivelytransportedbythecarrier-mediateduptakesystem.SLC19A1playsaroleinmaintainingintracellularconcentrationsoffolate.Transportoffolatecompoundsintomammaliancellscanoccurviareceptor-mediated(seeMIM136430)orcarrier-mediatedmechanisms.Afunctionalcoordinationbetweenthese2mechanismshasbeenproposedtobethemethodoffolateuptakeincertaincelltypes.Methotrexate(MTX)isanantifolatechemotherapeuticagentthatisactivelytransportedbythecarrier-mediateduptakesystem.RFC1playsaroleinmaintainingintracellularconcentrationsoffolate.[suppliedbyOMIM].