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Usbio/171561-FITC Mouse Anti-Ferritin (FITC)/171561-FITC/100ul
Ferritinisimportantinironhomeostasis.Itisthemainiron-storageprotein,composedoftwopartiallyhomologoussubunits,heavyandlightchains.Ferritinmoleculesincellscontaininghighlevelsofirontendtoberichinlightchains,andmayhavealong-termstoragefunction,whereasheavy-richferritinsaremoreactiveinironmetabolism.Mutationsintheferritingenecausethehereditaryhyperferritinemia-cataractsyndromeandneuroferritinopathy,associatedwithinflammation.Elevatedlevelsofferritinarereportedascharacteristicofadult-onsetStill'sdiseaseandhemophagocyticsyndrome,alsoassociatedwithinflammation.MICROFILamentsandincreasedlevelsofexogenousferritinareexcreteddirectlyintothebilebywayofasecondmicrofilament-independent,chloroquine-insensitivepathway,supportingapossIBLephysiologicalmechanismforthereleaseofferritinfromtheliver.