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Usbio/R9700-05A-AP Mouse Anti-Rubella, E1 (German Measles) (AP)/R9700-05A-AP/100ul
RubellavirusistheonlymemberoftheRubrivirusgenusoftheTogavirusfamily.UnlikemostTogavirusesitisNOTarthropodborne,butisacquiredviatherespiratoryroute.Itisanenveloped(toga=cloak),non-segmented,positivesense,RNAvirusandreplicatesinthecytoplasm.Itconsistsof3structuralproteins;E1,E2membraneboundglycoproteinsandCcapsidprotein.E1envelopeglycoproteinisaclassIIviralfusionprotein.FusionactivityisinactiveaslongasE1isboundtoE2inmaturevirion.Aftervirusattachmenttotargetcellandendocytosis,acidificationoftheendosomeinducesdissociationofE1/E2heterodimerandtrimerizationoftheE1subunits.ThisE1homotrimerisfusionactive,andpromotesreleaseofviralnucleocapsidinthecytoplasmaftercellandviralmembranefusion.TheE1cytoplasmictailmodulatesvirusrelease,andthetyrosinesresiduesarecriticalforthisfunction.
