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Usbio/C4275-35J-APC Mouse Anti-Cholera Toxin, Beta (Vibrio Cholerae, Cholera Enterotoxin Beta, Choleragenoid, CTX B, CTXB, CTX-B, TOXB, VC1456) (APC)/C4275-35J-APC/100ul
CholeratoxinisanoligomericproteinofMW84kDandconsistsofasingleAsubunitsurroundedbyfiveBsubunits.ItisapotentactivatorofadenylatecyclaseandisthepathogenicagentresponsIBLeforthesymptomsofcholera.TheBsubunit(choleragenoid)isresponsibleforthebindingoftheholotoxintoGM1gangliosidereceptorsonmammaliancellsurfacesandfacilitatesentranceoftheAsubunitintothecell.TheAsubunitbearstheADP-ribosyl-transferaseactivity,whichderegulatestheGsproteincausingactivationofadenylatecyclase.DuetotheubiquitousoccurrenceoftheGM1gangliosidereceptoroneukaryoticcellmembranes,choleratoxinactivatesadenylatecyclaseinawidevarietyofsystems.|CholeratoxinhasbecomeapowerfulresearchtoolnotonlyinmicroBIOLOGy,butinthefieldsofphysiology,cellbiologyandbiochemistry,aswell.Becauseoftheeffectonadenylatecyclase,choleratoxinanditspurifiedAsubunitarefrequentlyusedforthestudyofsignaltransductionmechanisms.Inaddition,choleratoxinactsasanadjuvantthroughthestimulationofB-lymphocytes.ThecholeratoxinBsubunitaloneisusedfortracktracinginneurologicalresearch,takingadvantageofGM1gangliosidebindingandretrogradetransport.
