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Usbio/134147-Biotin Mouse Anti-SYP (Synaptophysin, Major Synaptic Vesicle Protein P38) (Biotin)/134147-Biotin/100ul
Synaptophysin(p38)isanabundantintegralmembraneproteinofsmallsynapticvesiclesinthebrain.Itisalsopresentinendocrinecells,whereitisassociatedwithsmallelectron-translucentvesicles.SynaptophysinexpressionhasbeenwidelyusedasaMarkerforsynaptogenesisindevelopmentalstudiesinvivoandinvitroandasamarkerforneuron-specificcelllineagesintumorsofthecentralnervoussystemandofperipheralneuroendocrinecellderivation.Ithasmultipletransmembraneregionsandacytoplasmictailthatcontains10copiesofatyrosine-richrepeat.Biochemicalexperimentshavedemonstratedthatittransversesthemembranefourtimesandhascytoplasmiccarboxyl-andamino-termini.Italsocontainunstableintramoleculardisulfidebondsthatspontaneouslyrearrange,therebycreatinghigher-orderpolymersthatarelargerthanthenativeproteinandthathavedistinctlydifferentbiochemicalproperties.MutationsinvolvingthesynaptophysingenemayberesponsIBLeforanX-linkeddisorder.ChromosomallocalizationofthehumangeneforsynaptophysinestablishedthehumanSYPlocusontheXchromosomeinsubbandsXpll.22-pll.23.Itisinvolvedinstructuralfunctionsasorganizingothermembranecomponentsorintargetingthevesiclestotheplasmamembrane.
