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Usbio/213532-PE Rabbit Anti-SPARC (Secreted Protein Acidic And Rich In Cysteine, Osteonectin, ON) (PE)/213532-PE/100ul
SPARC(secretedproteinacidicandrichincysteine),alsoknownasosteonectinandBM40,isasecretedmatricellularglycoproteinthatbelongstoagroupoffunctionallyrelatedglycoproteinsthatincludestenascinsCandX,thrombospondins1and2,andosteopontin(1).Membersinthisclassofglycoproteinsareinvolvedintissuerenewal,tissueremodeling,andembryonicdevelopmentandworkbyexertingcounter-adhesiveandantiproliferativeeffectsthatleadtochangesincellshape,disruptionofcelladhesion,andinhibitionofthecellcycle(2).SPARCisexpressedathighlevelsinbonetissuebutiswidelydistributedinmanyothertissuesandcelltypes(3),andisknowntobeassociatedwithtissuesundergoingmorphogenesis,angiogenesis,mineralization,andotherpathologicalresponsestoinjuryandtumOrigenesis(4,5).SPARChasalsobeenlinkedwithobesityanddiabetes(6).
